An Overview of UDP-Glucose Pyrophosphorylase in Plants

doi:10.1007/s12042-024-09379-9

	An Overview of UDP-Glucose Pyrophosphorylase in Plants
	Zhang, Wenqi
	2025-12
发表期刊	TROPICAL PLANT BIOLOGY
ISSN	1935-9756
卷号	18 期号:1
摘要	Uridine diphosphate-glucose (UDP-Glc) plays a pivotal role as an essential precursor in cytoplasmic sucrose biosynthesis and provides Glc as a critical building block for synthesizing various macromolecules such as polysaccharides, proteins, and lipids through glycosylation reactions. These include the synthesis of cellulose, hemicellulose, and cell wall polysaccharides. Moreover, UDP-Glc acts as a signaling molecule implicated in both biotic and abiotic stress responses by triggering the MAP kinase cascade and ROS signaling pathways. The synthesis of UDP-Glc in plants is primarily catalyzed by the UDP-Glc pyrophosphorylase (UGPase) enzyme, exhibiting tissue-specific variations in catalytic direction. In source tissues such as leaves, UGPase uses Glucose-1-phosphate (Glc-1-P) and UTP as substrates to produce UDP-Glc and PPi. In non-photosynthetic sink tissues, UGPase catalyzes a pyrophospholytic reaction on UDP-Glc to Glc-1-P for the demand of metabolic processes. Plants possess two distinct types of UGPases, UGPase-A and UGPase-B. The former has an approximate molecular weight of 50-55 kDa and predominantly localizes within the cytoplasm, while the latter weighs around 90 kDa and resides within chloroplasts. UGPase exists in both monocotyledonous and dicotyledonous plants, functioning as monomers when active. The UGPase gene family in plants typically consists of a number of two or three genes, encoding two types of UGPases. Deficiency in UGPase leads to growth inhibition, developmental constraints, reduced levels of soluble sugars and starch, impaired callose deposition in pollen resulting in male sterility, and compromised cell wall integrity. Conversely, overexpression of the UGPase gene promotes accelerated growth rate, increased plant height, significantly elevated levels of soluble sugars and cellulose content, as well as enhanced stress tolerance. Consequently, UGPase emerges as a promising candidate gene for agricultural improvement.
关键词	UDP-glucose UGPase Soluble sugar Stress tolerance Plant
其他关键词	SUGAR PYROPHOSPHORYLASE ; N-ACETYLGLUCOSAMINE-1-P URIDYLYLTRANSFERASE ; ARABIDOPSIS-THALIANA ; SUCROSE METABOLISM ; STRUCTURAL BASIS ; EXPRESSION ; RICE ; GENE ; SYNTHASE ; STRESS
DOI	10.1007/s12042-024-09379-9
收录类别	SCIE
语种	英语
WOS研究方向	Plant Sciences
WOS类目	Plant Sciences
WOS记录号	WOS:001345392700001
出版者	SPRINGER
原始文献类型	Review
EISSN	1935-9764
引用统计	被引频次：1[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.library.ouchn.edu.cn/handle/39V7QQFX/172557
专题	国家开放大学江苏分部
通讯作者	Zhang, Wenqi
作者单位	Jiangsu Open Univ, Coll Environm & Ecol, Nanjing 210017, Peoples R China
第一作者单位	国家开放大学江苏分部
通讯作者单位	国家开放大学江苏分部
第一作者的第一单位	国家开放大学江苏分部
推荐引用方式 GB/T 7714	Zhang, Wenqi. An Overview of UDP-Glucose Pyrophosphorylase in Plants[J]. TROPICAL PLANT BIOLOGY,2025,18(1).
APA	Zhang, Wenqi.(2025).An Overview of UDP-Glucose Pyrophosphorylase in Plants.TROPICAL PLANT BIOLOGY,18(1).
MLA	Zhang, Wenqi."An Overview of UDP-Glucose Pyrophosphorylase in Plants".TROPICAL PLANT BIOLOGY 18.1(2025).