Synthesis of Novel 4(3H)-Quinazolinones with 1,2,3-Triazoles Moiety Conjugated by Schiff Base

doi:10.14233/ajchem.2014.17499

	Synthesis of Novel 4(3H)-Quinazolinones with 1,2,3-Triazoles Moiety Conjugated by Schiff Base
	Su, Changhui 1; Liu, Xia 2
	2014-08
发表期刊	ASIAN JOURNAL OF CHEMISTRY
ISSN	0970-7077
卷号	26 期号:16 页码:5301-5304
摘要	We describe the synthesis of a novel quinazolin-4(3H)-ones i.e., (E)-3-[ 4-{4-(hydroxymethyl)-1H-1,2,3-triazol-1-yl} benzylideneamino]-7-fluoro-2-methylquinazolin-4(3H)-one (7). Treatment of 4-(4-(hydroxymethyl)-1H-1,2,3-triazol-1-yl)benzaldehyde, which is synthesized via a click reaction of 4-azidobenzaldehyde and alkyne, with 3-amino-7-fluoro-2-methylquinazolin-4(3H)-one afforded the corresponding product in toluene catalyzed by TiCl4. in vitro Cytotoxic activity of compound 7 against human hepatoma hepg2 cells is evaluated.
关键词	Quinazolin-4(3H)-ones ANTIINFLAMMATORY ACTIVITY Cytotoxic activity AGENTS Schiff base AGONISTS 1,2,3-Triazoles AZIDES
DOI	10.14233/ajchem.2014.17499
收录类别	SCIE
语种	英语
WOS研究方向	Chemistry
WOS类目	Chemistry, Multidisciplinary
WOS记录号	WOS:000343767000079
出版者	ASIAN JOURNAL OF CHEMISTRY
原始文献类型	Article
EISSN	0975-427X
引用统计	被引频次：9[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.library.ouchn.edu.cn/handle/39V7QQFX/168346
专题	国家开放大学江苏分部
通讯作者	Su, Changhui
作者单位	1.Nanjing Univ, Jinling Coll, Chem & Life Sci Coll, Nanjing 210089, Jiangsu, Peoples R China; 2.Jiangsu Open Univ, Dept Sci & Technol, Nanjing 210036, Jiangsu, Peoples R China
推荐引用方式 GB/T 7714	Su, Changhui,Liu, Xia. Synthesis of Novel 4(3H)-Quinazolinones with 1,2,3-Triazoles Moiety Conjugated by Schiff Base[J]. ASIAN JOURNAL OF CHEMISTRY,2014,26(16):5301-5304.
APA	Su, Changhui,&Liu, Xia.(2014).Synthesis of Novel 4(3H)-Quinazolinones with 1,2,3-Triazoles Moiety Conjugated by Schiff Base.ASIAN JOURNAL OF CHEMISTRY,26(16),5301-5304.
MLA	Su, Changhui,et al."Synthesis of Novel 4(3H)-Quinazolinones with 1,2,3-Triazoles Moiety Conjugated by Schiff Base".ASIAN JOURNAL OF CHEMISTRY 26.16(2014):5301-5304.