| Anti-obesity effects of the high molecular weight Cordyceps militaris polysaccharide CMP40 in high-fat diet mice | |
| Wu, Yingyin1,2,3; Zhang, Yifeng1,2,3; Huang, Shishi1,2,3; Xie, Weifan4; Huang, Genan1,2,3; Zou, Yuan1,2,3; Ye, Zhiwei1,2,3; Wei, Tao1,2,3; Lin, Junfang1,2,3; Zheng, Qianwang1,2,3 | |
| 2024-08 | |
| 发表期刊 | FOOD BIOSCIENCE
 |
| ISSN | 2212-4292 |
| 卷号 | 60 |
| 摘要 | Crude Cordyceps militaris polysaccharides (CMPs) have been proven to be effective in alleviating harmful effects of a long-term high-fat diet (HFD), but there are fewer related studies on identifying the health-regulating abilities of certain subcomponents of CMPs. This study aimed to figure out the main component of CMPs in anti-obesity and to further explore its regulatory effects in vivo. Results showed among three main subcomponents (CMP40, CMP60 and CMP80) of CMPs, the large molecular weight CMP40 (with average molecular weight of more than 100 kDa) has shown superior in vitro hypoglycemic and hypolipidemic capacities. The simultaneous intervention of CMP40 indicated that it could reduce the body weight and white adipose tissue mass/area in the HFD mice. Serum parameters also suggested a decrease in the cholesterol and triglyceride level in the CMP40 group. These results might be due to the down-regulation of lipid synthesis and the up-regulation of lipolysis pathways. Besides, CMP40 could alleviate the inflammatory condition, such as the lower LPS and inflammatory cytokines levels, in the HFD mice in a dose-dependent manner. It could also restore gut health by increasing the SCFAs level, regulating gut microbiota structure, and repairing intestinal tight junction. Results also confirmed safe in CMP40 consumption since there were no side-effects on a high concentration addition of CMP40 (8%) to a regular diet. These findings suggested the promising anti-obesity effect of CMP40 and provided a theoretical basis of its further application in food industry. |
| 关键词 | Cordyceps militaris polysaccharide High -fat diet Anti-obesity |
| 其他关键词 | LIPID-METABOLISM ; GUT MICROBIOTA ; STRUCTURAL-CHARACTERIZATION ; OBESITY ; KEY ; INFLAMMATION ; ADIPOKINES ; LIVER ; ACIDS |
| DOI | 10.1016/j.fbio.2024.104467 |
| 收录类别 | SCIE |
| 语种 | 英语 |
| WOS研究方向 | Food Science & Technology |
| WOS类目 | Food Science & Technology |
| WOS记录号 | WOS:001257690500001 |
| 出版者 | ELSEVIER |
| 原始文献类型 | Article |
| EISSN | 2212-4306 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.library.ouchn.edu.cn/handle/39V7QQFX/171587 |
| 专题 | 国家开放大学 |
| 通讯作者 | Zheng, Qianwang |
| 作者单位 | 1.South China Agr Univ, Coll Food Sci, Guangzhou 510640, Peoples R China; 2.South China Agr Univ, Inst Food Biotechnol, Guangzhou 510640, Peoples R China; 3.Res Ctr Microecol Agent Engn & Technol Guangdong, Guangzhou 510640, Peoples R China; 4.Guangdong Open Univ, Guangdong Polytech Inst, Guangzhou 510091, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, Yingyin,Zhang, Yifeng,Huang, Shishi,et al. Anti-obesity effects of the high molecular weight Cordyceps militaris polysaccharide CMP40 in high-fat diet mice[J]. FOOD BIOSCIENCE,2024,60. |
| APA | Wu, Yingyin.,Zhang, Yifeng.,Huang, Shishi.,Xie, Weifan.,Huang, Genan.,...&Zheng, Qianwang.(2024).Anti-obesity effects of the high molecular weight Cordyceps militaris polysaccharide CMP40 in high-fat diet mice.FOOD BIOSCIENCE,60. |
| MLA | Wu, Yingyin,et al."Anti-obesity effects of the high molecular weight Cordyceps militaris polysaccharide CMP40 in high-fat diet mice".FOOD BIOSCIENCE 60(2024). |
| 条目包含的文件 | 条目无相关文件。 | |||||
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