Association of premature birth and maternal education level on attention deficit hyperactivity disorder in children: A meta-analysis

doi:10.5498/wjp.v14.i12.1956

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	Association of premature birth and maternal education level on attention deficit hyperactivity disorder in children: A meta-analysis
	Zhao, Yin-Kai 1; Li, Meng 2; Shi, Ting-Ting 1; Feng, Miao-Miao 3; Hu, Lu-Lu 1
	2024-12-19
发表期刊	WORLD JOURNAL OF PSYCHIATRY
ISSN	2220-3206
卷号	14 期号:12
摘要	BACKGROUND Attention deficit hyperactivity disorder (ADHD) is a prevalent neurodevelopmental disorder in childhood. There is growing evidence that both preterm birth and maternal education levels substantially affect the likelihood of ADHD in children. However, there are limited systematic reviews and meta-analyses examining these associations. AIM To systematically review and conduct a meta-analysis on the association of preterm birth and maternal education level on the risk of ADHD in children. METHODS We conducted a comprehensive literature search across MEDLINE (PubMed), Web of Science, Embase, and the Cochrane Library, including studies published up to June 17, 2024. Data synthesis was performed using random-effect models, and the quality of studies was assessed using the Newcastle-Ottawa Scale. RESULTS This study included twelve studies, which revealed a significant association between premature delivery and an increased risk of ADHD in children [odds ratio (OR) = 2.76, 95% confidence interval (CI): 2.52-3.04, P < 0.001, I-2 = 1.9%). Conversely, higher maternal education levels were significantly associated with a reduced risk of ADHD in children (OR = 0.59, 95%CI: 0.48-0.73, P < 0.001, I-2 = 47.1%). Subgroup analysis further indicated that maternal education levels significantly influenced ADHD risk, particularly in studies conducted in China (OR = 0.59, 95%CI: 0.46-0.75, P < 0.001, I-2 = 81.2%), while no significant association was observed in studies from other regions (OR = 1.25, 95%CI: 0.66-2.40, P = 0.495, I-2 = 92.3%). The sensitivity analysis confirmed the robustness of our findings, showing no significant publication bias. CONCLUSION This study found that preterm birth significantly increases the risk of ADHD in children, while a higher maternal education level serves as a protective factor against ADHD. To reduce the incidence of ADHD in children, public health policies should focus on early intervention for preterm infants and improving maternal education levels.
关键词	Attention deficit hyperactivity disorder Maternal education level Meta-analysis Preterm birth Systematic review
其他关键词	PRETERM BIRTH ; DEFICIT/HYPERACTIVITY DISORDER ; DEPRESSIVE SYMPTOMS ; RISK-FACTORS ; ADHD ; OUTCOMES ; MOTHERS ; FAMILY ; BORN ; AGE
DOI	10.5498/wjp.v14.i12.1956
收录类别	SCIE
语种	英语
资助项目	Henan Medical Science and Technology Research Joint Construction Project [LHGJ20190360]
WOS研究方向	Psychiatry
WOS类目	Psychiatry
WOS记录号	WOS:001385934400021
出版者	BAISHIDENG PUBLISHING GROUP INC
原始文献类型	Article
引用统计	被引频次：1[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.library.ouchn.edu.cn/handle/39V7QQFX/174310
专题	国家开放大学
通讯作者	Hu, Lu-Lu
作者单位	1.Zhengzhou Univ, Affiliated Hosp 3, Dept Obstet & Gynecol 3, 7 Kangfuqian St, Zhengzhou 450052, Henan, Peoples R China; 2.Henan Open Univ, Acad Marxism, Zhengzhou 450061, Henan, Peoples R China; 3.Zhengzhou Cent Hosp, Dept Neuroelectrophysiol, Zhengzhou 450007, Henan, Peoples R China
推荐引用方式 GB/T 7714	Zhao, Yin-Kai,Li, Meng,Shi, Ting-Ting,et al. Association of premature birth and maternal education level on attention deficit hyperactivity disorder in children: A meta-analysis[J]. WORLD JOURNAL OF PSYCHIATRY,2024,14(12).
APA	Zhao, Yin-Kai,Li, Meng,Shi, Ting-Ting,Feng, Miao-Miao,&Hu, Lu-Lu.(2024).Association of premature birth and maternal education level on attention deficit hyperactivity disorder in children: A meta-analysis.WORLD JOURNAL OF PSYCHIATRY,14(12).
MLA	Zhao, Yin-Kai,et al."Association of premature birth and maternal education level on attention deficit hyperactivity disorder in children: A meta-analysis".WORLD JOURNAL OF PSYCHIATRY 14.12(2024).